The Relation of Product Formulation to Absorption of Oral Theophylline

摘要: To assess the potential for therapeutic problems related to bioavailability of oral theophylline preparations, we examined rate and extent absorption various formulations in adult volunteers. Absorption from a solution or uncoated tablets was rapid complete. Three six sustained-release were more slowly, but still completely consistently, absorbed. other three appeared be erratic less Serum concentration-time curves during multiple eight-hour dosing simulated bioavailable preparations. With it predicted that fluctuations serum concentrations between doses would decrease, as compared with tablets, clinically important extent, particularly children, whom elimination is generally rapid.