摘要: Early detection of cancer would facilitate better management patients, because survival is greatly affected by stage presentation. Circulating nucleic acids represent a biomarker that might be used in the early cancer. In addition, such biomarkers could potentially to follow progression patients with DNA methylation promoter region CpG islands genes represents one acid-based marker, and possesses some advantages over other approaches. These include stability as molecule, ability detect changes using simple polymerase chain reaction-based approaches, potential for methylated preferentially present nucleosomes plasma or serum. factors are presented their impact on circulating bloodstream demonstrated.