Circulating methylated DNA.

作者: JAMES G. HERMAN

DOI: 10.1196/ANNALS.1318.006

关键词:

摘要: Early detection of cancer would facilitate better management patients, because survival is greatly affected by stage presentation. Circulating nucleic acids represent a biomarker that might be used in the early cancer. In addition, such biomarkers could potentially to follow progression patients with DNA methylation promoter region CpG islands genes represents one acid-based marker, and possesses some advantages over other approaches. These include stability as molecule, ability detect changes using simple polymerase chain reaction-based approaches, potential for methylated preferentially present nucleosomes plasma or serum. factors are presented their impact on circulating bloodstream demonstrated.

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