Mechanism of HIV-1 Entry into CD4+ T Cells

摘要: Although the mechanism responsible for HIV-1 entry into susceptible CD4+ T cells is incompletely understood, a number of key components are now known. For example, tropism expressing CD4 membrane glycoprotein reflects use this protein as specific viral receptor to which gp120 envelope binds with high affinity. This binding apparently results in exposure hydrophobic domains gp41 transmembrane apposing plasma components, resulting fusion and membranes one another which, turn, releases RNA cytosol. event, requisite well associated syncytia formation, occurs pH-independent fashion, but requires antecedent cell activation. In absence stimuli, resting resistant entry, may explain observation that at any given time vast majority seropositive patients not infected despite presence relatively large quantities free virus blood such patients. The other types, macrophages dendritic cells, remains be determined.