Infections and Iron: Too Much of a Good Thing?

摘要: The hypothesis that an iron-rich environment in the host predisposes to infection continues raise questions about safety of large parenteral doses iron, orally administered and even smaller quantities iron found iron-fortified foods. This commentary focuses on background laboratory data establishes link between increased bacterial virulence surveys existing clinical related administration susceptibility infection. POSSIBLE MECHANISMS RELATED TO IRON AND INFECTION There are several theoretical ways which might be associated with risk It is well known plays important role metabolism many species. Additionally, can negate bacteriostatic effects iron-binding proteins such as transferrin lactoferrin, present serum human cow's milk. Another mechanism by