Mechanisms of Itch Evoked by β-Alanine

摘要: β-alanine, a popular supplement for muscle building, induces itch and tingling after consumption, but the underlying molecular neural mechanisms are obscure. Here we show that, in mice, β-alanine elicited itch-associated behavior that requires MrgprD, G-protein-coupled receptor expressed by subpopulation of primary sensory neurons. These neurons exclusively innervate skin, respond to heat, mechanical noxious stimuli do not histamine. In humans, intradermally injected induced neither wheal nor flare, suggesting was mediated Thus, responsive likely part histamine-independent circuit target treating clinical is unrelieved anti-histamines.