摘要: In a randomized, prospective trial of 100 patients, we have studied the safety and efficacy warfarin sodium in comparison with that dextran 40 prevention venous thrombosis patients at high risk for deep vein after elective total hip or knee replacement. Warfarin was given new two-step regimen designed to avoid bleeding complications while still preventing thrombosis. A low dose started ten 14 days preoperatively, prothrombin time regulated between 1.5 3 seconds longer than control surgery; immediately surgery, increased prolong times control. The overall incidence as documented by venography less 53 treated 37 (21% v 51%), thrombi femoral popliteal veins (2% 16%). Objective measures blood loss showed no difference dextran, excessive postoperative infrequent similar both treatment groups. This study demonstrates therapy provides highly effective prophylaxis prosthetic surgery without perioperative bleeding. (JAMA1983;249:374-378)
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