Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation

摘要: . Objective.  The major function of the circadian system is internal cycling physiological and metabolic events. present study sought to explore effect rotating shift work schedule on leucocyte count its relationship with risk factors syndrome (MS). Design participants.  From a population-based design, 1351 men self-reported European ancestry were included in cross-sectional study: 877 day workers compared 474 workers. Medical history, health examination including anthropometric arterial blood pressure measurements, questionnaire health-related behaviours biochemical determinations was given all participants. Results.  In comparison workers, had elevated (mean ± SE) body mass index (27.1 ± 0.3 vs. 26.3 ± 0.2, P < 0.0154), waist-hip ratio (0.95 ± 0.01 0.93 ± 0.01, P < 0.00024), diastolic (78 ± 1 76 ± 1, P < 0.033), fasting insulin (65.5 ± 2.9 55.9 ± 1.9 pmol L−1, P < 0.017), Homeostasis Model Assessment (2.12 ± 0.11 1.77 ± 0.07, P < 0.0027), triglycerides (1.71 ± 0.1 1.5 ± 0.1 mmol L−1, P < 0.002), uric acid (292.7 ± 2.8 282 ± 3.4 μmol L−1, P < 0.01) (7030 ± 84 6730 ± 58, P < 0.0094). multiple regression analysis, correlated independently age, smoking, education components MS. Conclusion.  odds for MS 1.51 (95% CI 1.01–2.25), age physical activity. Increased count, biological marker systemic inflammation, associated work.