作者: Leonard P. Freedman , Iain M. Cockburn , Timothy S. Simcoe
DOI: 10.1371/JOURNAL.PBIO.1002165
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摘要: Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays costs of therapeutic drug development. An analysis past studies indicates that the (total) prevalence irreproducible preclinical exceeds 50%, resulting in approximately US$28,000,000,000 (US$28B)/year spent on is not reproducible—in United States alone. We outline a framework for solutions plan long-term improvements will help accelerate discovery life-saving therapies cures.