Odor-evoked category reactivation in human ventromedial prefrontal cortex during sleep promotes memory consolidation.

摘要: Slow-wave sleep is an optimal opportunity for memory consolidation: when encoding occurs in the presence of a sensory cue, delivery that cue during enhances retrieval associated memories. Recent studies suggest cues might promote consolidation by inducing neural reinstatement cue-associated content sleep, but direct evidence such mechanisms scant, and relevant brain areas supporting these processes are poorly understood. Here, we address gaps combining novel olfactory cueing paradigm with object-location task simultaneous EEG-fMRI recording human subjects. Using pattern analysis fMRI ensemble activity, find presentation odor promotes reactivation category-level information ventromedial prefrontal cortex significantly correlates post-sleep performance. In identifying potential which selectively modulate sleeping brain, findings bring unique insights into elucidating how what remember.