Induced parturition and retained placenta in the cow

摘要: In order to study rapid changes in 1 5-kctodihydro-PGF2, (PG-metabolite), the period preceding parturition cattle, prc-term was induced by dcxamcthasonc injection four heifers on days 254 265 gestation. Blood samples were collected at least every hour until 12 hours after and during second stage of labour 6 times per hour. The average time from 7.7 (mean). Two had retained foetal membranes (RFM). At start experiment levels PG-metabolite low increased slowly between 1000 2000 pmoliL one day before parturition. During last day, however, rapidly highest (>10000 pmoliL) reached delivery. No pulsatile elevations seen. Immediately expulsion decreased all animals. two animals with RFM, this decline ceased within a few postpartum (pp). Instead PG- metabolite started increase as high another effects prostaglandin synthesis inhibitor, flunixin (F) oxytetracycline (T) evaluated cows RFM. As model for pre-term injections PGF2,. 22/24 After divided into different groups according treatment. Cows treated F, T, T+F or conservatively. There experiments treatment periods (3-6 d pp, placental shedding 11-14 shedding). Animals T -14 quicker recovery uterine infection than other cows. 3-6 did not shorten but altered bacterial flora. Furthermore, led improved appetite energy consumption. However, delayed detachment compared F influence clinical signs, involution. suppressed signifkantly PG only partially. significantly kinetics early profile treatments. Late elevation correlated duration cervical final study, we wanted evaluate meloxicam (M) an inhibitor inflammatory response elicited endotoxin (ET). possible effect A"-rcductasc 15-hydroxy prostanoatc dehydro- gcnasc, which catalysc flrst steps metabolism Four mid luteal phase used experiment. ET cortisol release. White blood cells, iron, zinc calcium affected well. dramatic. Prc-treatment M found abolish PG-release totally. release reduced general appearance several parameters suppressed. prevent pyrogenic ET. seems have no major