Effects of glucose-insulin-potassium on myocardial substrate availability and utilization in stable coronary artery disease. Studies on myocardial carbohydrate, lipid and oxygen arterial-coronary sinus differences in patients with coronary artery disease.

摘要: Abstract To assess the metabolic effects of myocardial substrate alteration In patients with coronary artery disease, glucose-insulin-potassium solution was administered intravenously for 30 minutes to 14 men stable angiographically documented disease. The (300 g glucose, 50 units regular insulin and 80 mEq potassium chloride per liter water) infused at a constant rate in each patient, but individual infusion rates ranged from 0.013 0.032 ml/kg min (4 10 mg glucose/kg min) patients. Simultaneous arterial sinus samples were obtained 15 minute intervals during control period again infusion; assayed lactate, free fatty acid oxygen content. all patients, infusion, glucose lactate increased levels fell; magnitude changes acids as related infusion. Arterial-coronary differences (A-C s ) correlated concentrations these substrates ( r = 0.66, 0.87 0.79, respectively). Regression analyses demonstrated thresholds uptake follows: 79 mg/100 ml; 300 μmole/liter; 100 200 μEq/liter. Finally most importantly, reduction A-C values after 0.64, P Myocardial availability may be an important determinant demand Infusion has potential alter availability, thus improving balance between supply.