Cerebral metastases pathology after radiosurgery

摘要: BACKGROUND To the authors' knowledge, comprehensive human pathologic investigations that explore fundamental radiosurgical effects on metastatic brain tumors are sparse in literature. The objective of this study was to analyze histopathologic findings a set clinically recurrent cerebral metastases after patients underwent stereotactic radiosurgery (SRS). METHODS In series 7500 who radiosurgery, 2020 (27%) harbored metastases. Eighteen (0.9%) subsequent craniotomy for tumor removal anywhere from 1 month 59 months they received high-dose irradiation. Histologic and immunohistochemical were performed surgically resected tissue specimens. These specimens within treatment volume tumor. RESULTS Light microscopy revealed 3 basic categories histologic responses: acute-type, subacute-type, chronic-type reactions. A moderate-to-intense inflammatory cell reaction seen responses well controlled neoplasms (i.e., had required disease >5 SRS), whereas missing or poorly (patients <5 SRS). This irradiated not peritumoral area nor areas remote volume. Immunohistochemical characterization demonstrated presence prominent CD68-positive macrophage CD3-positive T-lymphocyte populations. progressively severe vasculopathy also observed with increasing time radiosurgery. CONCLUSIONS Although causality has been established, brisk response more lesions which recurrences delayed. Cancer 2006. © 2006 American Society.