Does minimizing neuroleptic dosage influence hyponatremia

摘要: Neuroleptic dosage was reduced by 10% every 2 weeks in five male hyponatremic polydipsic patients with schizophrenia. Mean dose fell from 1980 +/- 1289 to 631 135 chlorpromazine equivalents/day over a mean of 12.2 until behavioral relapse occurred. During this time, serum sodium did not vary baseline levels (132.9 4.9 mEq/1), suggesting that minimizing neuroleptic does alter the severity hyponatremia these patients.