Immunologic studies in pernicious anemia.

摘要: Experiments were directed to the investigation of evidence a possible role cellular immunity in patients with pernicious anemia. Lymphocyte-rich peripheral leucocyte preparations from 29 anemia cultured presence variety containing potential antigens: these included human gastric juice, intrinsic factor (IF) preparations, and mucosal homogenates. Lymphocyte transformation was determined by measurement uptake tritiated thymidine into DNA. occurred when lymphocytes portion (3.4 per cent 37.5 cent) antigen preparations. noted none whose sera contained blocking antibodies factor. There no correlation between or absence lymphocyte serum parietal cell cytoplasmic antigen. These data on permit consideration that may participate pathogenesis