Primer: the practical use of biological markers of rheumatic and systemic inflammatory diseases.

摘要: Changes in the levels of serum components facilitate evaluation inflammatory reaction. In this article, use novel markers inflammation process, such as procalcitonin, ferritin and cytokines, classic markers, C-reactive protein, is reviewed. The assessment systemic by means laboratory tests often complements results medical examination. Traditionally, erythrocyte sedimentation rate leukocytosis with left shift are diagnostic for infectious diseases. acute-phase proteins—especially protein—are used to assess both presence any response treatment. determination protein may be advised three types pathological situation: infection, acute or chronic inflammation, metabolic risk. Procalcitonin useful a marker sepsis severe infection. concentration amyloid A predicts chances survival patients secondary (AA) amyloidosis. Ferritin its glycosylated form interest study specific diseases adult-onset Still's disease. Markers cartilage bone turnover complementary these inflammation. Although cytokine transiently crucial generation their usefulness clinic still under investigation. Serum concentrations inhibitors soluble receptors, well clinical treatment antagonists, might generate important information monitoring autoinflammatory