Drug volume fraction profile in the gel phase and drug release kinetics in hydroxypropylmethyl cellulose matrices containing a soluble drug.
作者： Paolo Colombo , Ruggero Bettini , Pier Luigi Catellani , Patrizia Santi , Nikolaos A. Peppas
DOI: 10.1016/S0928-0987(99)00039-1
关键词:
摘要: In the present work, drug volume fraction profiles of a colored and very soluble drug, buflomedil pyridoxal phosphate, in gel layer initially glassy hydroxypropylmethyl cellulose matrices were studied, using image analysis pictures during swelling release. The goal was to correlate release kinetics with dynamic behavior gradient layer. An inert (nonswellable) matrix, manufactured by substituting an polymer containing same amount prepared as well. color partially extracted region flux this matrix compared swellable matrix. dissolved observed. It demonstrated that does not only depend on diffusion erosion, but also dissolution relaxation.
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