Methods for the analysis of nonbenzodiazepine hypnotic drugs in biological matrices

摘要: Zopiclone, zolpidem and zaleplon (Z-drugs) are nonbenzodiazepine hypnotic drugs that used for the treatment of insomnia. These were developed with intent to overcome some disadvantages benzodiazepines, such as dependence next day sedation. In general, administered in oral doses daily widely biotransformed body. A large number analytical methods based on chromatographic electrophoretic techniques quantification Z-drugs their metabolites biological matrices have been reported. this review, bioanalytical reviewed focus placed sample preparation procedures separation used. Furthermore, these also reported abuse or drug-facilitated crime, screening simultaneously cover other included review.