Glycomics: towards bioinformatic approaches to understanding glycosylation.

摘要: Cell surface glycoconjugates control a variety of biological events including cell differentiation, homing to specific tissues, adhesion, virus/cell recognition and immunological recognition. The heterogeneity diversity these molecules present challenge understanding both their functions how those are encoded. Advances in biotechnology have led new methods for genome proteome study that allow the analysis entire genetic or protein content cell. Efforts towards systematic variations cellular are, contrast, infancy. Recent advances glycosylation related technology begun open up possibility exploring structure glycome manner. This review focuses on latest mass spectrometry, microarray-based computational technologies glycomics.