Therapeutic Approaches in Regenerative Medicine of Cardiovascular Diseases: From Bench to Bedside

摘要: Despite significant progress in medical research, which has led to lower infant mortality rates and increased life expectancy, cardiovascular diseases (CVDs) continue be the largest contributors of morbidity both developed developing countries. In fact, they are predicted leading cause death by 2020 responsible for 13.4% total world-wide deaths 2030. These have a multifactorial origin, notably nonmodifiable risk factors (CRFs) such as age, sex, race or family history, modifiable CRFs, including smoking, hypertension, hypercholesterolemia, diabetes mellitus hypertriglyceridemia (Picariello et al., 2011; Glynn & Rosner, 2005). Currently, there no effective treatments available many degenerative caused malfunction specific cells. this regard, main physiopathology CVDs is related ischaemic heart disease, approximately two-thirds patients surviving an acute myocardial infarction (AMI) left with debilitating congestive failure. AMI causes apoptosis necrosis cardiomyocytes, specialized differentiated cell population ventricular contraction, event cardiac function. The low selfrenewal rate these cells (~0.06% cardiomyocytes under normal conditions) produces, cases stress, remodelling non-ischaemic myocardium scar formation, increasing likelihood new crisis, progressive dilatation failure, ending (Torella 2007). Organ transplantation appropriate therapeutic strategy who suffered end-stage failure unresponsive conventional therapy but drawbacks donor incompatibility, can lead rejection eventually Graft Versus