Reciprocal interaction between bone and gonads.

摘要: The demonstration that the skeleton is an endocrine organ has enriched physiological importance of this tissue and advanced our understanding whole-organism homeostasis. Moreover, bone affects powerful regulators its own physiology such as glucose metabolism, energy expenditure, gonads brain, reinforced concept interdependence between organs. This notion particularly true for interplay gonads. On one hand, are essential growth, maturation maintenance via secretion sex steroid hormones. other returns favor to gonads, through osteocalcin (Ocn), which promotes testosterone biosynthesis following binding Gprc6a, a G-protein-coupled receptor. loss function mutation in GPRC6A leads intolerance male sterility human, expands biological relevance role suggests some extent implication onset reproductive metabolic human diseases.