Risk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysis.

摘要: Background There is no consensus whether tobacco smoking increases risk of tuberculosis (TB) infection, disease, or mortality. Whether this so has substantial implications for and TB control policies. Objective To quantify the relationship between active pulmonary mortality using meta-analytic methods. Methods Eight databases (PubMed, Current Contents, BIOSIS, EMBASE, Web Science, Centers Disease Control Prevention Tobacco Information Source [TIPS], Smoking Health Database [Institute Science Health], National Library Medicine Gateway) Cochrane Addiction Group Trials Register were searched relevant articles published 1953 2005. Study Selection Included epidemiologic studies that provided a relative (RR) estimate association (infection, mortality) stratified by (or adjusted for) at least age sex corresponding 95% confidence interval (CI) data calculation). Excluded reports extrapulmonary TB, conducted in populations prone to high levels rates case-control which controls not representative population generated cases, as well case series, reports, abstracts, editorials, literature reviews. Data Extraction Twenty-four included meta-analysis. Extracted study design, diagnostic details, type, outcomes. Synthesis A random-effects model was used pool across studies. Separate analyses performed infection (6 studies), disease (13 (5 studies). For summary RR 1.73 (95% CI, 1.46-2.04); estimates ranged from 2.33 1.97-2.75) 2.66 2.15-3.28). This suggests an 1.4 1.6 development infected population. The RRs mostly below RRs, suggesting additional those with TB. Conclusions meta-analysis produced evidence factor disease. However, it clear causes persons who already have Tuberculosis policies should future incorporate preventive intervention.