Micronucleophagy: a new mechanism to protect against chromosomal instability?

摘要: Micronuclei are small membrane-enclosed cytoplasmic bodies containing whole or fragmented chromosomes, which formed during anaphase in aberrant mitosis and response to genotoxic stress. the latter scenario, formation of micronuclei can be used assess toxicity various chemicals drugs. A report by Rello- var ona et al. a previous issue describes elimination autophagy. 1 Macroautophagy (hereafter referred as autophagy) is highly regulated cellular mechanism for degradation recycling contents. This process begins with an autophagosome, double membrane structure that engulfs parts cytosol organelles, finally fusing lysosome allow enclosed material. The final products, including amino acids, lipids nucleotides, released into cyto sol via permeases present at lysosomal then anabolic reactions maintain functions. Autophagy conserved from yeast human Atg family proteins. 2