Dose dependent effects of chronic exposure to toluene on neuronal and glial cell marker proteins in the central nervous system of rats.
作者： J Huang , N Asaeda , Y Takeuchi , E Shibata , N Hisanaga
DOI: 10.1136/OEM.49.4.282
关键词:
摘要: The dose dependent effects of chronic exposure to toluene on the neuronal marker proteins (gamma-enolase, calbindin-D28k) and glial cell (alpha-enolase, creatine kinase-B, beta-S100 protein) were investigated in central nervous system (CNS) rats. Three groups animals exposed 100 ppm, 300 or 1000 ppm vapour eight hours a day, six days week for 16 weeks. contents substances determined with enzyme immunoassays. A significant increase three was noted cerebellum after toluene; more pronounced occurred at higher concentrations. protein also exhibited brainstem spinal cord. On other hand, two markers did not show quantitative decrease CNS. This means that development gliosis, rather than neurone death, is induced by toluene. biochemical changes around threshold limit value concentration alterations suggest these nerve specific may be used evaluate solvent related damage
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