Hypertension, thrombosis, kidney failure, and diabetes: Is covid-19 an endothelial disease? a comprehensive evaluation of clinical and basic evidence
作者： Celestino Sardu , Jessica Gambardella , Marco Bruno Morelli , Xujun Wang , Raffaele Marfella
DOI: 10.3390/JCM9051417
关键词:
摘要: The symptoms most commonly reported by patients affected coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 (e.g., high blood pressure, arterial venous thromboembolism, kidney disease, neurologic disorders, diabetes mellitus) indicate that the virus is targeting endothelium, one largest organs human body. Herein, we report a systematic comprehensive evaluation both clinical preclinical evidence supporting hypothesis endothelium key target organ COVID-19, providing mechanistic rationale behind its systemic manifestations.
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