Pharmacologic treatment of rhinitis.

摘要: Major improvements in the quality of recent pharmacologic studies rhinitis are evident. In many studies, criteria for patient selection being more carefully described and patients with allergic rhinitis, nonallergic eosinophilia, vasomotor no longer grouped together. most efficacy is still ascertained by subjective symptom scores, although some challenge investigators making noble attempts to quantitate symptoms objectively, eg, amount secretions, sneezing, even itching nares. Although nasal congestion only one chronic various methods measuring resistance rhinometry increasingly well standardized. General concepts that emerging from vast literature on treatment as follows: 1) The much-maligned H1 receptor antagonists may actually be useful than previously thought, once further information about how use them optimally available. Interesting new antihistamines developed. Further investigations allied drugs such tricyclic antidepressants (doxepin) definitely order. 2) alpha-adrenergic agonists have short-term usefulness but side effects this class have, if anything, been underestimated. Exploration beta-adrenergic anti-cholinergics has begun. 3) Disodium cromoglycate not universally effective perhaps part because compliance a prophylactic drug requiring insufflation four or six times daily high. degree response percentage having an excellent lower corticosteroids. 4) Topical corticosteroids administered intranasally clearly medications rhinitis. study benefit versus long-term risk these mandatory, their remarkable safety undisputed. Some comparisons between major groups now made, define relative roles interactions used needed.