Hepatic artery chemoembolization for 110 gastrointestinal stromal tumors

摘要: BACKGROUND. The efficacy of hepatic artery chemoembolization (HACE) was evaluated for gastrointestinal stromal tumors (GISTs) metastatic to the liver. METHODS. Records patients with GIST who underwent HACE between January 1993 and March 2005 were reviewed cross-sectional images used determine objective tumor response. Progression-free survival in liver (PFS-liver) overall (OS) calculated Kaplan–Meier method. Patient, tumor, treatment variables analyzed identify factors influencing survival. RESULTS. Of 110 identified, radiologic response could be 85 patients, 12 whom (14%) demonstrated partial responses, 63 (74%) stable disease, 10 (12%) progressive disease. PFS-liver rates 31.2%, 8.2%, 5.4% at 1, 2, 3 years, respectively; median PFS time 8.2 months. OS 62% 1 year, 32% 2 20% years; 17.2 Patients had >5 metastases received only found have a shorter compared fewer or those ≥2 sessions. Extensive involvement, presence extrahepatic metastases, progression disease after associated poor OS. Use imatinib prolonged time. CONCLUSIONS. HACE produced durable stabilization majority GISTs liver. Extent number embolization treatments, use prognostic influence on PFS, OS, both. Cancer 2006. © 2006 American Society.