DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes.
作者： Alesya A Fokina , Dmitry A Stetsenko , Jean-Christophe François
DOI: 10.1517/14712598.2015.1025048
关键词:
摘要: Introduction: Ongoing studies on the inhibition of gene expression at mRNA level have identified several types specific inhibitors such as antisense oligonucleotides, small interfering RNA, ribozymes and DNAzymes (Dz). After its discovery in 1997, 10-23 Dz (which can cleave RNA efficiently site-specifically, has flexible design, is independent from cell mechanisms, does not require expensive chemical modifications for effective use vivo) been employed to downregulate a range therapeutically important genes. Recently, Dzs taken their first steps into clinical trials.Areas covered: This review focuses predominantly applications potential antiviral, antibacterial, anti-cancer anti-inflammatory agents well treatment cardiovascular disease diseases CNS, summarizing results trials up present day.Expert opinion: In comparison with oligonucleotides RNAs, do usually show off-tar...
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