Lead dosage and the role of the intranuclear inclusion body. An experimental study.

摘要: Biological parameters known to be affected in lead poisoning were measured rats following ingestion of graded dosages lead. Intranuclear inclusion bodies are formed renal tubular lining cells with smaller doses than produce other changes. Decreased body weight is the next most sensitive abnormality. This followed by increased delta-aminolevulinic acid (ALA) excretion, reticulocytosis, edema, and aminoaciduria. Anemia only occurs at highest dosage. Over a wide range ingestion, urinary excretion remains constant, although content increases. Quantitative analyses cell organelles show that concentrated within bodies. Relatively small amounts present cytoplasm mitochondria. It suggested soft-tissue accumulates intranuclear body, thereby sparing toxic injury cytoplasmic organelles.