Compositions and methods for the treatment of metabolic bone disorders and bone metastases

摘要: Methods and compositions useful for targeting treating target tissues affected by or involved in metabolic bone disorders metastases with photodynamic therapy (PDT) a mammalian subject are provided. The biphosphonates, pyrophosphates, biphosphonate-like compounds conjugated to photosensitive agents which optionally further ligands tissue specific antibodies, peptides, polymers. method of PDT treatment utilize these the cells be treated. methods include irradiating at least portion light wavelength absorbed said photosensitizing agent that under conditions activation during using relatively low fluence rate, but an overall high total dose results minimal collateral damage.