Physicochemical Perspectives on the Cariostatic Mechanisms of Systemic and Topical Fluorides

摘要: The cariostatic mechanisms of systemic and topical fluoride agents are considered in light a previously proposed model for the caries process. It is noted that fluoride, principle, can induce effect: by (1) reducing enamel solubility when incorporated into mineral structure; (2) fostering remineralization incipient lesions deposition fluoridated phases (within dental plaque) which provide source ions (Ca, P, F) under acidic conditions; (3) net rate transport matter out surface, conditions, inducing reprecipitaion hydroxyapatite within enamel. also relatively high (~ 12,000 ppm) concentrations professionally applied fluorides significantly reduce acid production cariogenic organisms (e.g., S. mutans). Based on an analysis available clinical laboratory data, it concluded benefits provided water fluo...