Liver fatty acid‐binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPAR‐α in fasting mice

摘要: SPECIFIC AIMS1. Liver fatty acid binding protein (L-FABP) is the main cytosolic site for long chain acids (LCFA) in hepatocytes. Here we elucidated significance of L-FABP hepatic oxidation vivo.2. In cell culture, has been shown to increase activity and levels peroxisome proliferator-activated receptor α (PPARα), a transcription factor that boosts ketogenesis. We tested whether required action PPARα under fasting conditions.PRINCIPAL FINDINGS1. Long ketogenesis are reduced null liverBlood β-hydroxybutyrate were measured, as they derived mainly from mitochondrial LCFA oxidation. Mice subjected starvation, high fat/low sugar (ketogenic) diet, standard or high-fat/high-sugar (diabetogenic) diet. Figure 1⤻ A shows vs. wild-type mice, significantly all ketogenic conditions whereas circul...