Early Interleukin-6 and Slope of Monocyte Human Leukocyte Antigen-DR: A Powerful Association to Predict the Development of Sepsis after Major Trauma
作者： Aurélie Gouel-Chéron , Bernard Allaouchiche , Caroline Guignant , Fanny Davin , Bernard Floccard
DOI: 10.1371/JOURNAL.PONE.0033095
关键词:
摘要: Objective Major trauma is characterized by a pro-inflammatory response, followed an immunosuppression. Recently, in patients, the lack of recovery monocyte Human Leukocyte Antigen DR (mHLA-DR, biomarker ICU-acquired immunosuppression) between days 1–2 and 3–4 has been demonstrated to be independently associated with sepsis development. The main objective this study was determine whether early measurements IL-6 (interleukin-6) IL-10 plasma concentrations (as markers initial severity) could improve, association mHLA-DR recovery, prediction occurrence severe patients.
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