The safety and efficacy of antithyroid drugs.

摘要: Thionamides, selective inhibitors of thyroid peroxidase-mediated iodination by tyrosine residues in thyroglobulin, have been effectively used the treatment hyperthyroidism. The choices for initial patients with Graves' disease differ various countries, and many physicians around world prefer to administer thionamide drugs as first choice Although some thyroidologists more often consider radioiodine be because its safety ease administration, thionamides remain mainstay thyrotoxic children adolescents hyperthyroid women during pregnancy, postpartum period lactation. A recent study continuous shows efficacy, cost-benefit properties. Further studies effectiveness therapy thyrotoxicosis need designed implemented determine indications such children, adults diffuse toxic goiter, particular, those who had recurrence hyperthyroidism after discontinuation one complete course treatment.