CTLA-4 (CD152) Inhibits the Specific Lysis Mediated by Human Cytolytic T Lymphocytes in a Clonally Distributed Fashion
作者： Claudya Tenca , Fabrizio Manca , Daniele Saverino , Anna M. Megiovanni , Ermanno Ciccone
DOI:
关键词:
摘要: Since the functional outcome of effector T lymphocytes depends on a balance between activatory and inhibitory receptors, we studied ability CTLA-4 (CD152) to inhibit cytolytic function CTL. In 22 TCRαβ+CD3+8+ CTL clones, activation induced by anti-CD3, anti-CD28, or anti-CD2 mAb was inhibited anti-CD152 in redirected killing assay. eight clones inhibition >40%, 10 it ranged 20–40%, four 40% increment target cell lysis achieved three studied. is not equally shared all this feature also appears be clonally distributed.
jimmunol.org 参考文章(35)
Peter S. Linsley, Alejandro Aruffo, Gina Leytze, Nitin K. Damle, Kerry Klussman, Sigrid Myrdal, Jeffrey A. Ledbetter, Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7. Journal of Immunology. ,vol. 152, pp. 2686- 2697 ,(1994)
J A Bluestone, Is CTLA-4 a master switch for peripheral T cell tolerance? Journal of Immunology. ,vol. 158, pp. 1989- 1993 ,(1997)
A. Chandraker, J. W. Kupiec-Weglinski, P. S. Linsley, M. H. Sayegh, M. Schaub, S. Korom, K. Onodera, T. H. W. Stadlbauer, R. Peach, CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses. Journal of Immunology. ,vol. 159, pp. 1711- 1717 ,(1997)
William C. Gause, Peter S. Linsley, Marsha Wills-Karp, Andrea Keane-Myers, Shen Jue Chen, B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. Journal of Immunology. ,vol. 158, pp. 2042- 2049 ,(1997)
Jeffrey A. Bluestone, Theresa L. Walunas, CTLA-4 Regulates Tolerance Induction and T Cell Differentiation In Vivo Journal of Immunology. ,vol. 160, pp. 3855- 3860 ,(1998)
Carl H. June, Tara Francomano, Bruce L. Levine, James L. Riley, Steven J. Perfetto, Kelvin P. Lee, Patrick J. Blair, Nancy Craighead, Gary S. Gray, Beatriz M. Carreno, Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-XL Induction Journal of Immunology. ,vol. 160, pp. 12- 15 ,(1998)
Renato Zambello, Rosaria Sancetta, Gianpietro Semenzato, Fausto Adami, Marta Siviero, Michela Bortolin, Alessandra Perin, Carlo Agostini, Monica Facco, Umberto Basso, Andrea Cerutti, Livio Trentin, B Lymphocytes from Patients with Chronic Lymphoproliferative Disorders Are Equipped with Different Costimulatory Molecules Cancer Research. ,vol. 57, pp. 4940- 4947 ,(1997)
M L Alegre, C S Duckett, C B Thompson, E Chuang, M G Vander Heiden, P J Noel, Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. Journal of Immunology. ,vol. 159, pp. 144- 151 ,(1997)
Helios T. Leung, Jeff Bradshaw, Jeffrey S. Cleaveland, Peter S. Linsley, Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail Journal of Biological Chemistry. ,vol. 270, pp. 25107- 25114 ,(1995) , 10.1074/JBC.270.42.25107
L. E. M. Marengere, P. Waterhouse, G. S. Duncan, H.-W. Mittrucker, G.-S. Feng, T. W. Mak, Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4 Science. ,vol. 272, pp. 1170- 1173 ,(1996) , 10.1126/SCIENCE.272.5265.1170