Untangling Extracellular Proteasome-Osteopontin Circuit Dynamics in Multiple Sclerosis

摘要: The function of proteasomes in extracellular space is still largely unknown. proteasome-osteopontin circuit has recently been hypothesized to be part the inflammatory machinery regulating relapse/remission phase alternation multiple sclerosis. However, it unclear what dynamics there are between different elements circuit, role proteasome isoforms is, and whether these associated with clinical severity To shed light on aspects this novel we integrated vitro isoform data, cell chemotaxis culture data sclerosis cohorts a coherent computational inference framework. Thereby, modeled osteopontin-proteasome during Applying framework longitudinal study single patients suggests complex interaction osteopontin potential implications.