The Use of Oncolytic Vesicular Stomatitis Virus in Conjunction with Natural Products for the Treatment of Cervical Cancers

摘要: Vesicular Stomatitis Virus (VSV) is currently being studied as a candidate oncolytic agent due to its ability induce apoptosis in variety of cancer cells. Previous studies have shown that Matrix (M) protein mutants VSV, such rM51R-M virus, act selective anti-cancer agents by targeting cells while sparing normal Our goal was promote the use VSV for treatment cervical cancers. The cell line SiHa has been previous be permissive infection and killing VSV. We hypothesized lines are sensitized blockage type-1 interferon (IFN) response Human Papillomavirus (HPV) oncoproteins. However, our results indicated retained their respond type I IFN were sensitive both wild-type (wt) M mutant (rM51R-M virus) when infected at high multiplicity infection. Another line, C4-II, more resistant than To augment we presence natural compounds with known activities. Curcumin synergized kill C4-II cells, resveratrol, flavokavain B, Echinacea, quercetin did not offer an added benefit. In conclusion, show exhibit resistance but may VSV-induced oncolysis addition curcumin.