Development of photocrosslinkable hyaluronic acid‐polyethylene glycol‐peptide composite hydrogels for soft tissue engineering

摘要: Hyaluronic acid (HA; also called hyaluronan) is a naturally derived, nonimmunogenic, nonadhesive glycosaminoglycan that has important roles in several wound-healing processes. In previous work, we created photocrosslinkable glycidyl methacrylate-HA (GMHA) hydrogel biomaterials were cytocompatible, biologically active, and had decreased rate of hyaluronidase degradation compared with native HA. The goal the studies presented herein was to explore peptide conjugation techniques further adjust material biological properties GMHA hydrogels. We conjugated acrylated forms polyethylene glycol (PEG) PEG-peptides yield GMHA-PEG-peptide composite By varying reactant concentrations, stable hydrogels high efficiencies (up 80%), controllable concentrations (in range 1-6 micromol per milliliter hydrogel), defined physicochemical (e.g., swelling ratio, enzymatic rate). These may prove be promising scaffolding biomaterial for variety soft tissue engineering applications.