Biomarker-based risk assessment model in acute pulmonary embolism

摘要: Aims Despite growing interest in biomarkers application for risk evaluation acute pulmonary embolism (APE), no decision-making levels have been defined. Methods and results We developed a biomarker-based stratification 100 consecutive, normotensive on admission, APE patients (35 males, 65 females, 62±18 years). On admission serum NT-proBNP cardiac troponin T (cTnT) were assessed echocardiography was performed. All-cause 40-day mortality 15% 8%. In univariable analysis, cTnT>0.07 µg/L predicted all-cause mortality, hazard ratio (HR) 9.2 (95% CI: 3.3–26.1, P 7600 ng/L mortalities [HR 6.7 2.4–19.0, =0.0003) 7.3 1.7–30.6, =0.007)]. 0.07 µg/L the most significant independent predictor, whereas systemic systolic blood pressure measured echocardiographic parameters non-significant. with NT-proBNP≥600 ng/L cTnT≥0.07 µg/L reached 33%. NT-proBNP<600 ng/L indicated group without deaths. cTnT<0.07 µg/L 3.7%. Incorporation of data did not improve selection. Conclusion Simultaneous measurement cTnT allows precise prognosis. Normotensive are at high NTproBNP<600 ng/L indicates excellent