Oral contraceptives positively affect mood in healthy PMS-free women: A longitudinal study.

摘要: Abstract Objective Menstrual cycle phase and oral contraceptives (OC) use influence mood cognition these effects may be moderated by the mineralocorticoid receptor (MR) genotype. The effect of menstrual on increased if participants know that this is focus study. We assessed aspects associated with reproductive depression such as mood, interpersonal sensitivity, affect lability depressive cognitions in MR-genotyped OC-users naturally cycling (NC) women a carefully masked design. Methods A homogenous sample healthy, PMS-free, pre-menopausal (n = 92) completed online questionnaires eight times during two consecutive cycles. Results masking research question was successful. did not differ significantly from NC positive negative at time assessment, personality characteristics (e.g. neuroticism) or mental physical health. Both groups reported more shifts anger first week (p  p 2  = 0.08). Compared to women, fewer mood-shifts between elation mid-luteal (p = 0.002; η  = 0.10) had ruminating thoughts all phases (p = 0.003;  = 0.11). Effects MR-genotype were significant after correction for multiple comparisons. Conclusion OC users scored favorably measures depression. also showed decreased variability possibly indicating an emotional blunting effect, which line previous reports affect-stabilizing OC. Limitations loss cases due irregularities length possible confounding ‘survivor effect’, since almost took than year.