Alendronate affects long bone length and growth plate morphology in the oim mouse model for Osteogenesis Imperfecta.
作者： K.D Evans , S.T Lau , A.M Oberbauer , R.B Martin
DOI: 10.1016/S8756-3282(02)00974-2
关键词:
摘要: Alendronate, a bisphosphonate drug, has shown promise in reducing remodeling and bone loss postmenopausal osteoporosis. Alendronate acts directly on the osteoclast, inhibiting its resorption capability. This inhibition of osteoclast activity led to use bisphosphonates treatment osteogenesis imperfecta condition. Treatment with enhances strength, but consequences linear growth are not well defined. Using oim mouse model for type III imperfecta, two doses alendronate, low (0.125 mg/kg/wk) high (2.5 were administered weekly via intraperitoneal injection starting at 4 weeks age ending 12 assess effects alendronate humerus ulna length. The higher dose reduced length oim/wt wt/wt genotypes both sexes (P 2.5 inhibit long mice through alteration plate possibly chondro-osseous junction.
elsevier.com
sci-hub.se 参考文章(27)
D Vassilopoulos, G Karargiris, C Karatzetzos, D Karras, Reflex sympathetic dystrophy syndrome and osteogenesis imperfecta. A report and review of the literature. The Journal of Rheumatology. ,vol. 20, pp. 162- 164 ,(1993)
Hans-Peter Gerber, Thiennu H Vu, Anne M Ryan, Joe Kowalski, Zena Werb, Napoleone Ferrara, None, VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation Nature Medicine. ,vol. 5, pp. 623- 628 ,(1999) , 10.1038/9467
B Bembi, A Parma, M Bottega, S Ceschel, M Zanatta, C Martini, G Ciana, From Istituto di Clinica Pediatrica, Intravenous pamidronate treatment in osteogenesis imperfecta The Journal of Pediatrics. ,vol. 131, pp. 622- 625 ,(1997) , 10.1016/S0022-3476(97)70074-X
Caro Brumsen, Neveen A. T. Hamdy, Socrates E. Papapoulos, Long-term effects of bisphosphonates on the growing skeleton. Studies of young patients with severe osteoporosis. Medicine. ,vol. 76, pp. 266- 283 ,(1997) , 10.1097/00005792-199707000-00005
J. Saban, M.A. Zussman, R. Havey, A.G. Patwardhan, G.B. Schneider, D. King, Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta Bone. ,vol. 19, pp. 575- 579 ,(1996) , 10.1016/S8756-3282(96)00305-5
David A. Stevens, Graham R. Williams, Hormone regulation of chondrocyte differentiation and endochondral bone formation Molecular and Cellular Endocrinology. ,vol. 151, pp. 195- 204 ,(1999) , 10.1016/S0303-7207(99)00037-4
E R Lee, L Lamplugh, N L Shepard, J S Mort, The septoclast, a cathepsin B-rich cell involved in the resorption of growth plate cartilage.: Journal of Histochemistry and Cytochemistry. ,vol. 43, pp. 525- 536 ,(1995) , 10.1177/43.5.7730591
J. P. Devogelaer, J. Malghem, B. Maldague, C. Nagant de Deuxchaisnes, Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta. Skeletal Radiology. ,vol. 16, pp. 360- 363 ,(1987) , 10.1007/BF00350961
Katharina Bittner, Peter Vischer, Peter Bartholmes, Peter Bruckner, Role of the Subchondral Vascular System in Endochondral Ossification: Endothelial Cells Specifically Derepress Late Differentiation in Resting Chondrocytesin Vitro Experimental Cell Research. ,vol. 238, pp. 491- 497 ,(1998) , 10.1006/EXCR.1997.3849
Cornelia E. Farnum, Norman J. Wilsman, Cellular turnover at the chondro-osseous junction of growth plate cartilage: Analysis by serial sections at the light microscopical level Journal of Orthopaedic Research. ,vol. 7, pp. 654- 666 ,(1989) , 10.1002/JOR.1100070505