Multifunctional antimicrobial peptides: therapeutic targets in several human diseases

摘要: Antimicrobial peptides have emerged as promising agents against antibiotic-resistant pathogens. They represent essential components of the innate immunity and permit humans to resist infection by microbes. These gene-encoded are found mainly in phagocytes epithelial cells, showing a direct activity wide range microorganisms. Their role has now broadened from that simply endogenous antibiotics multifunctional mediators, their antimicrobial is probably not only primary function. Although peptide deficiency, dysregulation, or overproduction known be cause any single human disease, numerous studies provided compelling evidence for involvement complex network immune responses inflammatory diseases, thereby influencing diverse processes including cytokine release, chemotaxis, angiogenesis, wound repair, adaptive induction. The purpose this review highlight recent literature, associated with several conditions infectious discuss current clinical development peptide-based therapeutics future use.