Greater circulating DPP4 activity is associated with impaired flow-mediated dilatation in adults with type 2 diabetes mellitus

摘要: Abstract Background and aim Dipeptidyl peptidase 4 (DPP4) is a key enzyme involved in the regulation of incretin system exerted by cleaving glucagon-like peptide 1 (GLP-1); blockage DPP4, antidiabetic agents DPP4-inhibitors (DPP4-I), results greater GLP-1 concentration improved glycaemic control. DPP4 acts also as pro-inflammatory molecule mediates vascular damage experimental models. The relationship between activity endothelial function diabetes has not been explored yet. Aim this study was to investigate systemic plasma relation patients with type 2 mellitus (T2DM). Methods Sixty-two T2DM individuals were recruited our Diabetes outpatient clinics, Sapienza University, Rome, Italy. All participants underwent complete clinical work-up; evaluated flow-mediated dilatation (FMD) test; assessed measuring 7-amino-4-methylcoumarin (AMC) cleavage rate from synthetic substrate H-glycyl-prolyl-AMC compared measured sixty-two age-, sex-, BMI-matched non-diabetic subjects. Patients had significantly higher than (211,466 ± 87657 vs 158,087 ± 60267 nmol/min/ml, p  Conclusions Circulating increased associated signs dysfunction such impaired FMD. may negatively affect through mechanisms beyond glucose homeostasis metabolic