Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells.
作者： Wei Li , Ying Zhou , Jin Yang , Haining Li , Huanhuan Zhang
DOI: 10.3892/OR.2017.5637
关键词:
摘要: Abstract Curcumin possesses an anticancer effect against a wide assortment of tumors with selective cytotoxicity for tumor cells. However, the mechanism involved in curcumin‑induced remain unclear. In present study, we investigated efficacy curcumin human gastric cancer cell growth and molecular involved. Our results demonstrated that inhibited viabilities lines BGC-823, SGC-7901 MKN-28 both time- and dose-dependent manner. addition, treatment induced apoptosis dose‑responsive Western blotting apoptosis‑related proteins further confirmed pro-apoptotic potential curcumin. After exposure to curcumin, robust induction autophagy was observed cells, which characterized by formation acidic vesicular organelles (AVOs), conversion LC3-I LC3-II increase levels autophagy‑related proteins. Activation PI3K/Akt/mTOR signaling pathway suppressed cells treatment. administration inhibitor 3-methyladenine (3-MA) significantly promoted apoptotic death Collectively, our findings provide new evidence induces protective in vitro. Autophagy may novel effective strategy improving cancer.
sci-hub.se 参考文章(35)
David T. Coleman, Young Hwa Soung, Young-Joon Surh, James A. Cardelli, Jun Chung, Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0125399
Xiaolong Wang, Wenwen Qi, Yaming Li, Ning Zhang, Lun Dong, Mingjuan Sun, Jinjing Cun, Yan Zhang, Shangge Lv, Qifeng Yang, Huaier Extract Induces Autophagic Cell Death by Inhibiting the mTOR/S6K Pathway in Breast Cancer Cells PLOS ONE. ,vol. 10, pp. e0131771- ,(2015) , 10.1371/JOURNAL.PONE.0131771
Peng Zou, Junru Zhang, Yiqun Xia, Karvannan Kanchana, Guilong Guo, Wenbo Chen, Yi Huang, Zhe Wang, Shulin Yang, Guang Liang, ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer. Oncotarget. ,vol. 6, pp. 5860- 5876 ,(2015) , 10.18632/ONCOTARGET.3333
Xiaohong Liu, Kai Sun, Hao Chen, Ailin Song, Xiaoyun Zhang, Xu Zhang, Xiaodong He, None, Curcumin inhibits proliferation of gastric cancer cells by impairing ATP-sensitive potassium channel opening World Journal of Surgical Oncology. ,vol. 12, pp. 389- 389 ,(2014) , 10.1186/1477-7819-12-389
MAO-SHU ZHANG, FU-WEN NIU, KUN LI, Proflavin suppresses the growth of human osteosarcoma MG63 cells through apoptosis and autophagy Oncology Letters. ,vol. 10, pp. 463- 468 ,(2015) , 10.3892/OL.2015.3206
Hugo Ford, Ioannis Gounaris, Docetaxel and its potential in the treatment of refractory esophagogastric adenocarcinoma. Therapeutic Advances in Gastroenterology. ,vol. 8, pp. 189- 205 ,(2015) , 10.1177/1756283X15585468
Katarzyna Terlikowska, Anna Witkowska, Malgorzata Zujko, Bozena Dobrzycka, Slawomir Terlikowski, Potential application of curcumin and its analogues in the treatment strategy of patients with primary epithelial ovarian cancer. International Journal of Molecular Sciences. ,vol. 15, pp. 21703- 21722 ,(2014) , 10.3390/IJMS151221703
Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das, Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer ecancermedicalscience. ,vol. 9, pp. 525- 525 ,(2015) , 10.3332/ECANCER.2015.525
Wei Da, Jinshui Zhu, Long Wang, Qun Sun, Curcumin suppresses lymphatic vessel density in an in vivo human gastric cancer model Tumor Biology. ,vol. 36, pp. 5215- 5223 ,(2015) , 10.1007/S13277-015-3178-8
Steven Koprowski, Kevin Sokolowski, Selvi Kunnimalaiyaan, T. Clark Gamblin, Muthusamy Kunnimalaiyaan, Curcumin-mediated regulation of Notch1/hairy and enhancer of split-1/survivin: molecular targeting in cholangiocarcinoma Journal of Surgical Research. ,vol. 198, pp. 434- 440 ,(2015) , 10.1016/J.JSS.2015.03.029