Suncus murinus as a new experimental model for motion sickness.
作者： Shinya Ueno , Norio Matsuki , Hiroshi Saito
DOI: 10.1016/0024-3205(88)90520-6
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摘要: Characteristics of motion sickness and effects possible prophylactic drugs were studied using Suncus murinus (house musk shrew) for its potential use as an experimental model in sickness. Mild reciprocal shaking (amplitude: 10-40 mm; frequency: 0.5-3.0 Hz) induced vomiting most within 2 min. Adaptation was observed when the stimulus repeated with interval to 3 days. During repetitive training, both ratio sensitive animals number episodes decreased, time from start first extended. Subcutaneous injection scopolamine (100 mg/kg), chlorpromazine (8 promethazine (50 diphenhydramine (20 chlorphenylamine mg/kg) methamphetamine (2 decreased emetic effect sickness, but pyrilamine meclizine dimenhydrinate (32 not effective or very weak. These results indicate that is antiemetic are prophylaxis. The useful a new animal
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