Mechanotransduction in endothelial responses to shear stress: review of work in Dr. Chien's laboratory.

摘要: Shear stresses play an important role in vascular biology health and disease. While disturbed flows with low shear the bends bifurcations of arterial tree are atherogenic, laminar high straight part vessel is atheroresistant. Thus, elucidation mechanotransduction mechanism endothelial cells response to stress has become research topic among bioengineers biologists. Here a summary studies performed Dr. Shu Chien's laboratory on stress-induced signal transduction gene expression during period from 1992-1999. These studies, together efforts other groups, demonstrate that integrins, which transmembrane molecules interact both extracellular matrices intracellular cytoskeleton kinases focal adhesions, mechanotransduction. This hypothesis mainly supported by similarity between cellular molecular events elicited those activated integrin-mediated cell attachment matrices. Evidence also provided show dynamic specific interaction integrin essential for