Expression and Function of LPA1 in Bladder Cancer
作者： Masao Kataoka , Kei Ishibashi , Shin Kumagai , Tomohiko Yanagida , Ken Aikawa
DOI: 10.1016/J.JURO.2014.12.028
关键词:
摘要: Purpose: LPA is one of several physiologically active lipid mediators that promote cell proliferation and invasion, are present in serum, ascites urine. receptor a G-protein coupled considered potential therapeutic target for some malignant cancers. We evaluated the expression receptors bladder cancer effect invasion.Materials Methods: Using real-time polymerase chain reaction immunohistochemical staining we determined specimens from patients with cancer, including 12 Ta or T1 15 T2-T4 disease. ROCK expression, myosin light phosphorylation Matrigel™ invasion assays were done morphological observations made to assess effects T24 cells, which derived cancer.Results: Notably LPA1 mRNA was significantly higher muscle invasive than nonmuscle specimens. Strong expres...
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