Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study

摘要: Summary Background Multiple organ dysfunction syndrome is more frequent than death in paediatric intensive care units. Estimation of the severity this could be a useful additional outcome measure clinical trials such We aimed to validate logistic (PELOD) score and estimate its validity when recorded daily (dPELOD). Methods did prospective, observational, multicentre cohort study seven multidisciplinary, tertiary-care units university-affiliated hospitals (two French, three Canadian, two Swiss). included 1806 consecutive patients (median age 24 months; IQR 5–90). PELOD includes six dysfunctions 12 variables was daily. For each variable, most abnormal value day during whole stay were used calculating dPELOD scores, respectively. Outcome vital status at discharge. Hosmer-Lemeshow goodness-of-fit tests evaluate calibration areas under receiver operating characteristic curve (AUC) discrimination. Findings 370 (21%) had no dysfunction, 471 (26%) one, 457 (25%) two, 508 (28%) or more. Case fatality rate 6·4% (115 deaths). significantly higher non-survivors (mean 31·0[SE 1·2]) survivors (9·4[0·2]; p Interpretation scores are valid measures multiple units; their use should reduce sample size required complete critically ill children.