EXCITATORY AMINO ACID RECEPTORS IN THE CENTRAL NERVOUS SYSTEM

摘要: Speculation on the possible role played by physiologically occurring dicarboxylic amino acids L-aspartate and L-glutamate has continued from time that Hayashi (1954) first described marked excitatory action of latter compound general electrical activity cerebral cortex. Thereafter, potent effect these substances single neurons spinal cord was demonstrated (Curtis et al., 1960), similar studies have now been made cells in many other parts central nervous system (for references, see Johnson, 1972). Although an occasional apparently anomalous result reported (McLennan, 1971), it appears all or almost can be depolarized excited glutamate aspartate introduced into their immediate extracellular environments.