Multiscale regression modeling in mouse supraspinatus tendons reveals that dynamic processes act as mediators in structure–function relationships

摘要: Recent advances in technology have allowed for the measurement of dynamic processes (re-alignment, crimp, deformation, sliding), but only a limited number studies investigated their relationship with mechanical properties. The overall objective this study was to investigate role composition, structure, and response load predicting tendon properties multi-level fashion mimicking native hierarchical collagen structure. Multiple linear regression models were determine relationships between composition/structure, processes, Mediation then used if mediated structure-function relationships. Dynamic strong predictors These predictions location-dependent, insertion site utilizing all four responses midsubstance responding primarily fibril deformation sliding. In addition, moderately predicted by composition structure regionally-dependent manner. Finally, partial mediators composition/structure function, results suggested that mediation is likely shared multiple processes. conclusion, at are controlled region responds via Conversely, function many other important parameters mechanisms. Overall, presents foundation on which design future experimental modeling efforts order fully understand complex present tendon.