Nitric Oxide: Biological Synthesis and Functions

摘要: The pluripotent gaseous messenger molecule nitric oxide (NO) controls vital functions such as neurotransmission or vascular tone (via activation of soluble guanylyl cyclase), gene transcription, mRNA translation iron-responsive elements), and post-translational modifications proteins ADP-ribosylation). In higher concentrations, NO is capable destroying parasites tumor cells by inhibiting iron-containing enzymes directly interacting with the DNA these cells. view this multitude NO, it important to understand mechanisms which accomplish regulate production molecule. mammals, three isozymes synthase (NOS; L-arginine, NADPH:oxygen oxidoreductases, forming; EC 1.14.13.39) have been identified. These isoforms are referred neuronal “n”NOS (or NOS I), inducible “i”NOS II), endothelial “e”NOS III). pathophysiology, massive amounts produced hyperactive nNOS highly expressed iNOS can contribute processes neurodegeneration, inflammation, tissue damage. This chapter will describe principles biosynthesis, regulatory controlling molecule, large array (physiologic pathophysiologic) that Mother Nature has assigned small